Selected Publications by Scientific Board Members
- Retzbach, E.P., Sheehan, S.A., Krishnan, H., Zheng, H., Zhao, C., and Goldberg, G.S. (in press) Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration. Molecular Carcinogenesis.
- Sheehan, S.A., Retzbach, E.P., Shen, Y., Krishnan, H., and Goldberg, G.S. (2022) Heterocellular N-cadherin junctions enable nontransformed cells to inhibit the growth of adjacent transformed cells. Cell Communication and Signaling. 20 (19): 1-17
- Sheehan, S.A., Hamilton, K.L., Retzbach, E.P., Balachandran, P., Krishnan, H., Leone, P., Lopez-Gonzalez, M., Suryavanshi, S., Kumar, P., Russo, R., and Goldberg, G.S. (2021) Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progression. Experimental Cell Research. 403:112594-112560.
- Hamilton, K.L., Sheehan, S.A., Retzbach, E.P., Timmerman, C.A., Gianneschi, G.B., Tempera, P.J., Balachandran, P., and Goldberg, G.S. (2021) Effects of Maackia amurensis seed lectin (MASL) on oral squamous cell carcinoma (OSCC) gene expression and transcriptional signaling pathways. Journal of Cancer Research and Clinical Oncology. 147:445–457.
- Ralph, A.C.L., Valadão, I.C., Cardoso, E.C., Garcilazo, F.S.G., Martins, V.R., Oliveira, L.M.S., Bevilacqua, E.M.A.F., Geraldo, M.V., Jaeger, R.J., Goldberg, G.S., and Freitas, V.M. (2020) Environmental control of mammary carcinoma cell expansion by acidification and spheroid formation in vitro. Nature Scientific Reports. 10, 21959-21970.
- Krishnan, H., Miller, W.T., Blanco, F.J., and Goldberg, G.S. (2019) Src and podoplanin forge a path to destruction. Drug Discovery Today 24, 241-249.
- Krishnan, H., Rayes, J., Miyashita, T., Ishii, G., Retzbach, E.P., Sheehan, S.A., Takemoto, A., Chang, Y.-W., Yoneda, K., Asai, J., Jensen, L., Chalise, L., Natsume, A., and Goldberg, G.S. (2018) Podoplanin – an emerging cancer biomarker and therapeutic target. Cancer Science 109,1292-1299.
- Retzbach, E.P., Sheehan, S.A., Nevel, E., Batra, A., Phi, T., Kato, Y., Baredes, S., Fatahzadeh, M., Shienbaum, A.J., and Goldberg, G.S. (2018) Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target. Oral Oncology 8, 126–136.
- Silva, T.A., Smuczek, B., Valadão, I.C., Dzik, L.M., Iglesia, R.P., Cruz, M.C., Zelanis, A., de Siqueira, A.S., Serrano, S.M.T., Goldberg, G.S., Jaeger, R.G., Freitas, V.M. (2016) AHNAK enables mammary produce extracellular produce extracellular vesicles that increase neighboring fibroblast cell motility. Oncotarget. 7:49998-50016.
- Krishnan, H. and Goldberg, G.S. (2015) Contact normalization or escape from the matrix. In: Kandous, M. (Eds.) Intercellular communication and Cancer. pp. 297-342. Heidelberg: Springer-Verlag.
- Krishnan, H., Retzbach, E.P., Ramirez, M.I., Liu, T., Li, H., Miller, W.T., Goldberg, G.S. (2015) PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility. Experimental Cell Research. 335: 115-122.
- Ochoa-Alvarez, J.A., Krishnan, H., Pastorino, J.G., Nevel, E.M., Kephart, D., Lee, J.J., Retzbach, E.P., Shen, Y., Fatahzadeh, M., Baredes, S., Kalyoussef, E., Honma, M., Adelson, M.E., Kaneko, M.K., Kato, Y, Young, M.A., Deluca-Rapone, L., Shienbaum, A.J., Yin, K., Jensen, L.D., and Goldberg, G.S. (2015) Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms. Oncotarget, 6: 9045-90604.(highlighted in issue cover art)
- Kolar, K., Freitas-Andrade, M., Bechberger, J.F., Krishnan, H., Goldberg, G.S., Naus, C.C., and Sin, W.C. (2015) Podoplanin: a marker of reactive gliosis in gliomas and brain injury. Journal of Neuropathology and Experimental Neurology, 74: 64-74. (Highlighted in issue cover art).
- Mayan, M.D., Gago-Fuentes, R., Carpintero-Fernandez, P., Fernandez-Puente, P., Filgueira-Fernandez, P., Goyanes, N., Valiunas, V., Brink, P.R., Goldberg, G.S., and Blanco, F.J. (2015) Articular chondrocyte network mediated by gap junctions: Role in metabolic cartilage homeostasis. Annals of the Rheumatic Diseases, 74: 275-84.
- Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. Nature 501, 107-11, 2013.
- Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility. Journal of Biological Chemistry 288, 12215-12221, 2013.
- Src points the way to biomarkers and chemotherapeutic targets. Genes and Cancer 3, 426-435, 2012.
- Plant lectin can target receptors containing sialic Acid, exemplified by podoplanin, to inhibit transformed cell growth and migration. PLoS One 7:e41845, 2012.
- Structure of human mitochondrial RNA polymerase. Nature 478, 269-73, 2011.
- Src activates Abl to augment Robo1 expression in order to promote tumor cell migration. Oncotarget 4, 198-209, 2010.
- Src induces Pdpn expression to promote cell migration. Journal of Biological Chemistry 285, 9649-9656, 2010.
- TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase. Cell 139, 934-44, 2009.
- Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration. Oncogene 28, 4272-4283, 2009.
- Coordinate suppression of Sdpr and Fhl1 expression in tumors of the breast, kidney, and prostate.Cancer Science 99, 1326-1333, 2008.
- Src utilizes Cas to block gap junctional communication mediated by connexin43. Journal of Biological Chemistry 282, 18914-18921, 2007.
- Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and cellular transformation. Journal of Biological Chemistry 281, 20689-20697, 2006.
- Src utilizes Cas to suppress Fhl1 in order to promote nonanchored growth and migration of tumor cells.Cancer Research 66, 1543-1552, 2006.
- Structural basis for substrate selection by t7 RNA polymerase. Cell 116, 381-91, 2004.
- Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and Src activity. Cancer Research 64, 1347-1358, 2004.
- Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. Journal of Biological Chemistry 278, 46533-46540, 2003.
News Articles and Reviews
- RowanSOM researcher begins human trials for cancer treatment drug (2021) Rowan Today
- Sentrimed research profiled in Oncotarget Interviews with Outstanding Authors
- Sentrimed research presented at the 76th meeting of the Japanese Cancer Association meeting at Pacifico Yokohama (Sept 28-30, 2017)
- Sentrimed research presented at the International PDPN Meeting at Nagoya University (Oct 1, 2017)
- The Voice of Galicia November 24, 2013
- Science Daily – Bioactive Protein from Ancient Medicinal Plant May Help Combat Melanoma and Other Cancers
- Goldberg lab discovers novel cancer drug. SOM-UMDNJ 35th anniversary publication, 2012.pdf
- Vying for the title of world’s fastest cell – Science News, 2011.
- World’s first cell race no small affair – Nature News, 2011.
- Src and Abl hijack the Robo1 pathway